Entresto® FAQs

PBIRx®

Intelligent Solutions in Pharmacy Benefits

612 Wheelers Farms Road, Milford, CT 06461

(888) 797-2479

What is Entresto®?
Entresto® (sacubitril / valsartan) is a combination of two oral agents used for the treatment of heart failure. It belongs to a new class of drugs called the ARNI’s (angiotensin receptor and neprilysin inhibitors).

What is special about this drug?
One of its two agents – sacubitril - is a new type of drug that, in combination with valsartan, has been shown to have efficacy over existing heart failure treatments.

How much will it cost?
Expected cost is $15/day; $5000/year.

Is Entresto® currently available? 
Entresto® is expected to be on the market 3Q15.

How many people will use Entresto®?
Heart failure affects 5.7 million Americans. Over 800,000 cases are newly diagnosed each year. Entresto® has an estimated market of over 2 million U.S. lives.

What are the current drug treatments for heart failure?
Heart failure is currently treated with a series of older agents, most available generically. They have varying degrees of efficacy and side effects.

Is Entresto® safe?
Initial testing did not reveal any unknown side effects versus the therapy it was tested against. As with any drug there is the potential of side effects and adverse events. As new drugs are dispensed to a wider population we can expect more reports of side effects and adverse events.

What will the FDA do to ensure drug safety?
The FDA has required post-marketing studies to observe certain adverse trends noted in the drug testing.

For more information, please contact PBIRx at (888) 797-2479.